

According to legend, Siena was founded by Senius, son of Remus, who was in turn the brother of Romulus, after whom Rome was named. Statues and other artwork depicting a she-wolf suckling the young twins Romulus and Remus can be seen all over the city of Siena. Siena was an Etruscan settlement and a small Roman town, the seat of a Christian bishop by the 5th century, but its importance began in the early 12th century, when a self-governing commune replaced the earlier aristocratic government.
Siena's republic, struggling internally between nobles and the popular party, usually worked in political opposition to its great rival, Florence, and was in the 13th century predominantly Ghibelline in opposition to Florence's Guelph position.
Siena rivalled Florence in the arts through the 13th and 14th centuries: the important late medieval painter Duccio (1253–1319) was a Senese but worked across the peninsula. Siena was devastated by the Black Plague of 1348 and never recovered its earlier glory, losing out to Florence in inter-urban rivalry. Siena retained its independence in Tuscany until 1557.