The ancient city "urbs vetus" whence "Orvieto" populated in Etruscan times, has usually been associated with Etruscan Velzna. Orvieto was certainly a major center of Etruscan civilization;
Orvieto was annexed by Rome in the 3rd century BC. After the collapse of the Roman Empire its defensible site gained new importance: the episcopal see was transferred from Bolsena, and the city was held by Goths and by Lombards before its self-governing commune was established in the 10th century, in which consuls governed under a feudal oath of fealty to the bishop. From 1201 it governed itself through a podestà in concert with a military governor, the "captain of the people" but bitter feuds divided the 13th-century city.
Pope Boniface VIII was from Orvieto and donated statues of himself at the main city gates. During the Sack of Rome in 1527 the Pope took refuge at Orvieto, and fearing that in the event of siege by Charles' troops the city's water might prove insufficient, he had a spectacular well constructed (Pozzo di San Patrizio) by the architect-engineer Antonio di Sangallo the Younger (1527-37) with double helical ramps for one-way traffic, so that mules laden with water-jars might pass down then up again unobstructed. Its inscription boasts QUOD NATURA MUNIMENTO INVIDERAT INDUSTRIA ADIECIT ("what nature stinted for provision, let application supply")
A small university (now part of the University of Perugia), had its origins in a studium generale that was granted to the city by Pope Gregory XI in 1337. The territory of Orvieto was under papal control long before it was officially added to the Papal States, and it remained a papal possession until 1860 when it was annexed to the Kingdom of Italy